Priest Genjo Sanzo and companions Cho Hakkai, Sha Gojyo, and Son Goku maintain their westward journey to stop the resurrection of the demon Gyoumaoh. As the reputation of the Sanzo Ikkou precedes them, they continue to fight demon assassins at every turn, but they must also deal with increasing tensions within their group in order to defeat a powerful enemy.
- In 2006, Saiyuki Reload was recognize by PUFF dub as the "Manga Oscars" as one of the "Manga's Best Ten". It ranked 10th on the long stories category. 
- Saiyuki Reload Vol. 8 was ranked 6th best seller for the week (May 29- June 4), according to Tohan Japanese publisher's distributer.  A week later Saiyukir Reload Vol. 8 dip from 6th to 8th place.
- Volume 9 of Saiyuki Reload was rank 6th according to Tohan.
- The final volume of Saiyuki Reload sold almost 75,000 copies in preorders ranking it 7th according to Tohan and Oricon. .The succeeding week Saiyuki Reload Vol. 10 falls from 7th place to 18th (added almost 40,000 additinal copies).